Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ
نویسندگان
چکیده
منابع مشابه
1 Structural basis of Rev 1 - mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev 1 , heterodimeric Pol and
Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA These authors contributed equally to this work. Running title: Structure of the Rev1 CTD-Rev3/7-Pol RIR complex To whom correspondence should be address...
متن کاملRegulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link.
DNA interstrand cross-links (ICLs) are repaired in S phase by a complex, multistep mechanism involving translesion DNA polymerases. After replication forks collide with an ICL, the leading strand approaches to within one nucleotide of the ICL ("approach"), a nucleotide is inserted across from the unhooked lesion ("insertion"), and the leading strand is extended beyond the lesion ("extension"). ...
متن کاملCorrection: The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ
[This corrects the article DOI: 10.1371/journal.pgen.1007119.].
متن کاملREV1 and polymerase ζ facilitate homologous recombination repair
REV1 and DNA Polymerase ζ (REV3 and REV7) play important roles in translesion DNA synthesis (TLS) in which DNA replication bypasses blocking lesions. REV1 and Polζ have also been implicated in promoting repair of DNA double-stranded breaks (DSBs). However, the mechanism by which these two TLS polymerases increase tolerance to DSBs is poorly understood. Here we demonstrate that full-length human...
متن کاملDNA Repair: DNA Polymerase ζ and Rev1 Break in
seen in this study for verbs, in the processing of time and temporal structure [10]. While Shapiro et al. [3] are admirably restrained in their interpretations, they outline how their results suggest there is some relationship between grammatical class and semantic representations. This is a far from trivial issue: from a classic psycho-linguistic perspective, semantic and syntactic representat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.394841